Rage to Kill (1987)

Deep in the jungle, Nazi zealot Dr. Hoffmann has been hiding for 40 years, searching for a powerful weapon of science that will restore his dream of Nazi domination. Using the venom of a deadly jungle spider, he believes he's discovered such a weapon and, with his cohort, forms a plan to test his evil new serum on the population of LA. Meanwhile, a band of Nazi-hunters is closing in on them.